How to Calculate Glp1 Dose Titration

What is Glp1 Dose Titration?

The GLP-1 Dose Titration Schedule calculator maps out the FDA-approved dose escalation timeline for semaglutide and tirzepatide medications. It helps patients and providers plan each titration step, ensuring the correct dose is taken at the right time to minimize gastrointestinal side effects.

Formula

Next Dose Date = Current Dose Start + (Weeks per Titration Step × 7 days)

D₀: Starting Dose (mg) — Initial dose prescribed at titration start
D_max: Target Maintenance Dose (mg) — Maximum tolerated or prescribed dose
T: Titration Interval (weeks) — Duration at each dose level before escalating (typically 4 weeks)
N: Number of Steps (steps) — Total titration levels from starting to maintenance dose

Step-by-Step Guide

1Select your GLP-1 medication (semaglutide or tirzepatide) and indication (weight loss or diabetes)
2Enter your current dose and the date you started it
3The calculator generates a full titration calendar with each dose level and target date
4Review the schedule and set reminders for each dose escalation step

Worked Examples

Input

Semaglutide (Wegovy) starting 0.25 mg on Jan 1

Result

0.25 mg weeks 1-4, 0.5 mg weeks 5-8, 1.0 mg weeks 9-12, 1.7 mg weeks 13-16, 2.4 mg week 17 onward — maintenance dose reached by April 23

Input

Tirzepatide (Mounjaro) starting 2.5 mg on March 1

Result

2.5 mg weeks 1-4, 5 mg weeks 5-8, 7.5 mg weeks 9-12, 10 mg weeks 13-16, 12.5 mg weeks 17-20, 15 mg week 21 onward

Common Mistakes to Avoid

✕Skipping titration steps to reach the maintenance dose faster, which increases nausea and vomiting risk
✕Confusing Ozempic (max 2 mg) titration with Wegovy (max 2.4 mg) titration — they are different schedules
✕Not accounting for dose-delay periods when side effects require staying at a lower dose longer

Frequently Asked Questions

What happens if I miss a dose during titration?

If you miss a dose by less than 5 days (semaglutide) or less than 4 days (tirzepatide), take it as soon as possible. If more time has passed, skip the missed dose and resume on your regular schedule. Do not double up. Consult your provider about whether to restart the titration.

Can I titrate faster than the recommended schedule?

No. The FDA-approved titration schedule exists to reduce gastrointestinal side effects like nausea and vomiting. Skipping steps significantly increases adverse event rates and may lead to medication discontinuation.

Is the titration schedule the same for Ozempic and Wegovy?

No. Ozempic (for diabetes) titrates to a max of 2 mg with fewer steps, while Wegovy (for weight loss) titrates through five steps to 2.4 mg. The medications contain the same active ingredient but have different approved dosing regimens.