How to Calculate Partition Coefficient
What is Partition Coefficient?
Calculates partition coefficients describing how substances distribute between immiscible liquid phases.
Formula
Kp = [Solute in Phase A] / [Solute in Phase B]
Step-by-Step Guide
- 1Enter equilibrium concentrations in each phase
- 2Calculate the ratio of concentrations
- 3Interpret distribution preference
Worked Examples
Input
Drug concentration: 50 mg/mL water, 200 mg/mL octanol
Result
Kp = 0.25 (prefers water)
Drug solubility distribution
Common Mistakes to Avoid
- ✕Reversing phase concentrations
- ✕Confusing with distribution ratio for ionic species
Ready to calculate? Try the free Partition Coefficient Calculator
Try it yourself →