Uitgebreide gids binnenkort beschikbaar
We werken aan een uitgebreide educatieve gids voor de Insulin Dose Calculator. Kom binnenkort terug voor stapsgewijze uitleg, formules, praktijkvoorbeelden en deskundige tips.
The insulin dose calculator is a clinical decision-support tool that estimates three fundamental insulin dosing parameters: the correction dose (the amount of rapid-acting insulin needed to bring an elevated blood glucose back to target), the insulin sensitivity factor (ISF, also called the correction factor — how many mg/dL one unit of insulin lowers blood glucose), and the insulin-to-carbohydrate ratio (ICR, also called carb ratio — how many grams of carbohydrate one unit of insulin covers at a meal). These parameters are derived from the total daily dose (TDD) of insulin, which is the sum of all basal and bolus insulin units taken in a 24-hour period. The '1700 rule' (for mg/dL) or '94 rule' (for mmol/L) estimates ISF from TDD for rapid-acting analogues; the '1500 rule' applies to regular human insulin. The '500 rule' estimates the carb ratio for rapid-acting insulins; '450' is sometimes used for regular insulin. These rules provide starting estimates that must be validated and adjusted based on clinical response, continuous glucose monitoring data, carbohydrate counting accuracy, and individual metabolic variation. Insulin dose calculation is a critical safety skill for people with type 1 diabetes and increasingly for insulin-treated type 2 diabetes. Errors in insulin dosing account for a significant proportion of serious hypoglycaemic episodes and hospital admissions. The calculator empowers patients and clinicians to calculate and verify doses systematically rather than by guesswork.
ISF (mg/dL) = 1700 / TDD; ISF (mmol/L) = 94 / TDD; Carb Ratio (g/U) = 500 / TDD (rapid-acting) or 450 / TDD (regular); Correction Dose (units) = (Current BG - Target BG) / ISF
- 1Determine the total daily dose (TDD): sum all basal insulin units and all bolus insulin units taken over a typical 24-hour period.
- 2Calculate the Insulin Sensitivity Factor (ISF): divide 1700 by TDD for mg/dL units (or 94 for mmol/L). This estimates how many mg/dL (or mmol/L) one unit of rapid-acting insulin will lower blood glucose.
- 3Calculate the carbohydrate ratio (ICR): divide 500 by TDD for rapid-acting insulin (450 for regular insulin). This estimates grams of carbohydrate covered by one unit.
- 4Calculate the correction dose: subtract the target blood glucose from the current blood glucose, then divide by the ISF. Round to the nearest practical unit increment (0.5U or 1U depending on the delivery device).
- 5Calculate the meal bolus: divide the grams of carbohydrate in the meal by the ICR to get the carb-coverage dose.
- 6Combine correction and meal boluses as appropriate, always accounting for any insulin-on-board (active insulin from previous boluses, typically with a duration of 4-5 hours for rapid analogues).
- 7Validate these starting estimates against observed blood glucose responses over 5-7 days and adjust TDD-derived factors by 10-20% increments based on systematic glucose patterns.
Starting estimates — verify against actual glucose responses
A patient on 50 units per day has an estimated ISF of 34 mg/dL per unit. This means one unit of rapid-acting insulin should lower blood glucose by approximately 34 mg/dL. If the patient's blood glucose is 215 and target is 100, the correction dose is (215-100)/34 = 3.4 units, rounded to 3.5U.
Check insulin-on-board before administering
The blood glucose is 180 mg/dL above target. With an ISF of 40, 4.5 units should theoretically bring it to target. However, if the patient took a bolus within the past 4 hours, insulin-on-board must be subtracted to avoid stacking and hypoglycaemia.
Adjust for pre-meal glucose and expected activity
A meal with 60g carbohydrate at an ICR of 10g per unit requires 6 units of rapid-acting insulin. If pre-meal blood glucose is also elevated, add a correction dose to this meal bolus. If significant physical activity follows the meal, a reduction of 20-30% may prevent hypoglycaemia.
Combined meal + correction bolus
This patient needs 5 units to cover the meal and 1.5 units to correct the pre-meal hyperglycaemia, totalling 6.5 units. Modern insulin pumps and smart pens automatically calculate this combined bolus, but the underlying arithmetic must be understood by both patient and clinician.
Professionals in finance and lending use Insulin Dose Calculator as part of their standard analytical workflow to verify calculations, reduce arithmetic errors, and produce consistent results that can be documented, audited, and shared with colleagues, clients, or regulatory bodies for compliance purposes.
University professors and instructors incorporate Insulin Dose Calculator into course materials, homework assignments, and exam preparation resources, allowing students to check manual calculations, build intuition about input-output relationships, and focus on conceptual understanding rather than arithmetic.
Consultants and advisors use Insulin Dose Calculator to quickly model different scenarios during client meetings, enabling real-time exploration of what-if questions that would otherwise require returning to the office for detailed spreadsheet-based analysis and reporting.
Individual users rely on Insulin Dose Calculator for personal planning decisions — comparing options, verifying quotes received from service providers, checking third-party calculations, and building confidence that the numbers behind an important decision have been computed correctly and consistently.
Extreme input values
In practice, this edge case requires careful consideration because standard assumptions may not hold. When encountering this scenario in insulin dose calculatorulator calculations, practitioners should verify boundary conditions, check for division-by-zero risks, and consider whether the model's assumptions remain valid under these extreme conditions.
Assumption violations
In practice, this edge case requires careful consideration because standard assumptions may not hold. When encountering this scenario in insulin dose calculatorulator calculations, practitioners should verify boundary conditions, check for division-by-zero risks, and consider whether the model's assumptions remain valid under these extreme conditions.
Rounding and precision effects
In practice, this edge case requires careful consideration because standard assumptions may not hold. When encountering this scenario in insulin dose calculatorulator calculations, practitioners should verify boundary conditions, check for division-by-zero risks, and consider whether the model's assumptions remain valid under these extreme conditions.
| TDD (units/day) | ISF mg/dL per unit | ISF mmol/L per unit | ICR g carb per unit (rapid) |
|---|---|---|---|
| 20 | 85 | 4.7 | 25 |
| 30 | 57 | 3.1 | 17 |
| 40 | 43 | 2.4 | 13 |
| 50 | 34 | 1.9 | 10 |
| 60 | 28 | 1.6 | 8 |
| 80 | 21 | 1.2 | 6 |
| 100 | 17 | 0.9 | 5 |
What is the 1700 rule?
The 1700 rule (or 1700 formula) estimates the insulin sensitivity factor (ISF) for rapid-acting insulin analogues: ISF (mg/dL) = 1700 / TDD. It was developed empirically from clinical observations and is sometimes called the '94 rule' when working in mmol/L (94/TDD). The '1500 rule' applies to older regular human insulin, which has a longer duration of action.
What is insulin-on-board and why does it matter?
Insulin-on-board (IOB) refers to the amount of active insulin still working from a previous bolus. Rapid-acting analogues (lispro, aspart, glulisine) remain active for approximately 4-5 hours after injection. If a correction dose is calculated without subtracting IOB, the patient risks stacking insulin and developing significant hypoglycaemia. Insulin pumps and smart pens automatically track IOB.
Why does the carb ratio use 500 for rapid-acting but 450 for regular insulin?
Regular (soluble) insulin has a longer onset, peak, and duration of action compared to rapid-acting analogues. It requires slightly less insulin to cover the same carbohydrate load because it acts over a longer postprandial window. The 450 rule accounts for this pharmacokinetic difference. Modern therapy primarily uses rapid-acting analogues, so the 500 rule is more commonly applied.
How do I know if my ISF estimate is accurate?
Validate the ISF by observing blood glucose responses to correction doses taken when no meal is consumed and no physical activity occurs. If blood glucose consistently drops more than expected (more than the ISF predicts), the ISF is underestimated (true ISF is higher) — reduce the dose. If BG drops less than expected, the ISF is overestimated — increase the dose. Validation requires 5-7 consistent observations.
Do ISF and ICR vary by time of day?
Yes, significantly. Dawn phenomenon causes insulin resistance in the early morning, meaning the ISF is lower (each unit covers less BG reduction) and the ICR is lower (each unit covers fewer carbohydrates) at breakfast compared to other meals. Many patients with type 1 diabetes use different ICRs for breakfast versus other meals. Insulin pumps allow time-of-day programming of these ratios.
Should the same ISF and ICR apply to type 2 as type 1 diabetes?
The same formulae apply but type 2 diabetes is characterised by variable residual endogenous insulin secretion and greater insulin resistance, making TDD-based estimates less reliable. Starting estimates from these rules are used, but much more frequent and gradual dose titration is needed. Structured self-monitoring rather than formula calculation often guides dosing in type 2 diabetes.
What safety limits should be applied to calculated doses?
Most diabetes teams set a maximum correction dose (e.g., no more than 10% of TDD as a single correction) and recommend rechecking blood glucose 2-4 hours after a large correction. Patients should be educated never to give more than one correction dose within a 4-5 hour window without confirming persistent hyperglycaemia and checking for the absence of ketones.
How does exercise affect ISF?
Aerobic exercise markedly increases insulin sensitivity, effectively raising the ISF (each unit lowers BG more). This effect can persist for 12-24 hours after prolonged aerobic exercise. Patients need to reduce correction and meal boluses around exercise, consume additional carbohydrates, or use a temporary basal rate reduction on an insulin pump to prevent exercise-induced hypoglycaemia.
Pro Tip
The 1700 rule gives a starting ISF estimate, but the real ISF can vary 2-3 fold depending on time of day, physical activity, illness, and hormonal cycle. Use the formula as a starting point, then validate over a week of structured glucose monitoring before relying on it for all corrections.
Wist je dat?
The '1700 rule' for rapid-acting insulin was derived by Paul Davidson, an American endocrinologist, who noticed that the product of TDD and observed ISF was consistently close to 1700 across many patients. The rule was published in the 1990s and became a foundational teaching tool in structured diabetes education worldwide.
Referenties
- ›Walsh J, Roberts R. Pumping Insulin: Everything You Need for Success on an Insulin Pump. 5th ed. Torrey Pines Press 2011
- ›American Diabetes Association Standards of Medical Care 2024 — Pharmacologic Approaches to Glycaemic Treatment
- ›NICE NG17 — Type 1 Diabetes in Adults: Diagnosis and Management 2015 (updated 2022)
- ›Bergenstal RM et al. Safety of a hybrid closed-loop insulin delivery system. JAMA 2016